Drug Targeting and Design
Target drug delivery system is a marked form of drug delivery system. The therapeutic response of a drug based upon the interaction of drug molecules with cell on cell membrane interconnected biological events at receptor sites in a concentration-dependent manner. Targeted drug delivery entail for selective and functional localization of pharmacologically active moiety at pre recognized (preselected) target in therapeutic concentration, while moderate its entrance to non-target normal cellular linings, thus reduce toxic effects and increase therapeutic index. Targeting of drugs to marked cells and tissues of the body without their becoming a part of systemic circulation is a tremendous novel idea. If a drug can be distribute in a form such that it reaches the receptor sites' inadequate concentration without interrupting in extraneous tissue cells.
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